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Updated: Aug 18, 2026

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
1Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris, France. geberl@pasteur.fr
Abstract:
The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.
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