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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
[Clinical observation on effect of weichangshu in treating diabetic gastroparesis]
Yi Zhong1, Hong Zhou, Ling Zhong
1Institute of Piwei Research, Guangzhou University of TCM, Guangzhou. zhongyisir@21cn.com
Objective:
To observe the effect of Weichangshu (WCS) in treating diabetic gastroparesis (DGP).
Methods:
Ninety-six patients with DGP were randomly divided into two groups. Besides the same conventional blood glucose controlling regimen was given to both groups, WSC was given to the treated group and Mosapride Citrate tablet to the control group additionally. The treatment course for them was 4 weeks. Therapeutic effect on clinical syndromes was assessed, the fasting and 2-hr postprandial blood glucose, antro-duodenal interdigestive migrating motor complex (MMC) and electrogastrogram (EGG) were measured before and after treatment.
Results:
The therapeutic effect in the two groups were similar with no statistical significant difference. The time of MMC phase II was shortened, time of MMC phase III prolonged, and the constriction amplitude of which increased after treatment in both groups, showing significant difference as compared to those before treatment (P < 0.05). EGG were significantly changed after treatment mainly manifested as increase of proportional dominant frequency (PDF) and strengthening of proportional dominant amplitude (PDP ) (P <0.05 or P < 0.01). Besides, WSC also promoted the decrease of post-prandial blood glucose.
Conclusion:
WSC has dual effect in promoting gastric motility and decreasing blood glucose, with less adoerst reaction.