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Updated: Aug 18, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Can we diagnose, treat or even understand neurally mediated syncope?
Satish R Raj1, André Diedrich, Italo Biaggioni
1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville TN 37212, USA.
Abstract:
There are significant gaps in our understanding of the pathophysiology, diagnosis and treatment of NMS (neurally mediated syncope). Contributions in this area will be welcomed by patients and physicians taking care of them alike. In this issue of Clinical Science, Simek and co-workers report a novel non-invasive physiological measurement that does not require head-up tilt to diagnose NMS. However, validation studies applied to an unselected patient population are needed before we can judge how useful this test will be in the diagnosis of NMS.
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