Candidosis and aspergillosis as autopsy findings from 1994 to 2003

Area of Science:

• Medical Mycology
• Pathology
• Infectious Diseases

Background:

• Autopsy records from Greifswald University Institute of Pathology (1994-2003) were analyzed.
• Previous studies reported invasive fungal infection rates between 0.7% and 7.3%.

Purpose of the Study:

• To analyze trends in candidosis and aspergillosis prevalence over a 10-year period.
• To investigate the association of mycoses with underlying diseases and affected organs.
• To assess the role of autopsies in diagnosing and managing fungal infections.

Main Methods:

• Retrospective analysis of 2027 autopsy records.
• Statistical comparison of fungal infection rates between two 5-year periods (1994-1998 and 1999-2003).
• Examination of clinical data, including underlying diseases and affected organs.

Main Results:

• Invasive candidosis and aspergillosis were found in 8.1% of autopsies.
• A significant increase in mycoses and candidosis was observed over the study period.
• The gastrointestinal and respiratory tracts were more frequently infected by Candida in the latter 5 years.
• All eight immature aborted fetuses and premature infants studied had candidosis.
• Non-haematological neoplasia and pneumonia were common underlying diseases in candidosis cases.

Conclusions:

• Autopsies are crucial for understanding and controlling fungal infections.
• There is a concerning rise in invasive fungal infections, particularly candidosis.
• Early diagnosis and management of mycoses are essential, especially in vulnerable populations like premature infants.