Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischemic colitis associated with rofecoxib.

F Radaelli1, M Feltri, G Meucci

  • 1Department of Gastroenterology, Valduce Hospital, Via Dante 11, 22100 Como, Italy. gastro@valduce.it

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|April 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative metronidazole treatment to evaluate its efficacy in reducing <i>Fusobacterium nucleatum</i> colonisation in colorectal cancer patients: a proof-of-concept trial.

ESMO gastrointestinal oncology·2026
Same author

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2022
Same author

What gastroenterologists should know about direct oral anticoagulants.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2020
Same author

Analysis of patients attitude to undergo urgent endoscopic procedures during COVID-19 outbreak in Italy.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2020
Same author

Multiple sclerosis incidence in Tuscany from administrative data.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2018
Same author

Author Correction: μMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure.

Scientific reports·2018
Same journal

Fibrate therapy in primary sclerosing cholangitis: missing data on lipids, interactions, and cancer risk.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Pharmacovigilance of drug-induced microscopic colitis: time to consider exposure duration and dechallenge completeness.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

A rare cause of intermittent dysphagia successfully treated by endoscopic submucosal dissection.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Transfusion-dependent duodenal bleeding from portal hypertensive enteropathy: an endoscopic challenge.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Synchronous tumors at the esophagogastric junction: A triad of carcinomas in one ESD specimen.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
See all related articles

Two patients experienced self-limited ischemic colitis after taking 50mg of rofecoxib daily for acute pain. Symptoms resolved upon drug discontinuation, suggesting a potential link between rofecoxib and colon ischemia.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Rofecoxib, a selective cyclooxygenase-2 inhibitor, is approved for osteoarthritis and acute pain.
  • Concerns exist regarding its prothrombotic potential and cardiovascular safety, particularly at doses exceeding 25mg daily.

Observation:

  • Two extensively investigated cases of self-limited ischemic colitis are presented.
  • Both patients were treated with 50mg of rofecoxib daily for acute pain.

Findings:

  • Symptom onset in both cases correlated temporally with rofecoxib use.
  • Symptoms abated upon rofecoxib discontinuation.
  • No other causes for colon ischemia were identified.

Implications:

  • While a definitive causal link cannot be established, the temporal relationship between rofecoxib use and ischemic colitis is striking.

Related Experiment Videos

  • The findings suggest a potential pathophysiological mechanism linking rofecoxib to colon ischemia, warranting further investigation.
  • This highlights the importance of considering drug-induced adverse events in clinical diagnosis.