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Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress

Andreas Barthel1, Lars-Oliver Klotz

  • 1Abteilung für Endokrinologie, Diabetologie und Rheumatologie, Heinrich-Heine-Universität Düsseldorf, D-40225 Düsseldorf, Germany.

Biological Chemistry
|April 22, 2005
PubMed

Insights

Oxidative stress contributes to diseases by generating reactive oxygen species (ROS). This review explores how ROS activate the phosphoinositide 3-kinase (PI 3-kinase)/protein kinase B (PKB) pathway, linking oxidative stress to cell signaling in various diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Signaling

Background:

  • Oxidative stress, characterized by reactive oxygen species (ROS), is implicated in the pathogenesis of diseases like cancer, diabetes, and cardiovascular disorders.
  • ROS can cause non-specific cellular damage and activate specific signaling pathways, influencing disease development and progression.

Purpose of the Study:

  • To review the molecular mechanisms linking oxidative stress to the phosphoinositide 3-kinase (PI 3-kinase)/protein kinase B (PKB) signaling pathway.
  • To highlight the role of this pathway in regulating cellular survival and metabolism in the context of oxidative stress-related diseases.

Main Methods:

  • Literature review focusing on the molecular interactions between ROS and PI 3-kinase/PKB signaling.
  • Analysis of key regulatory systems involved in mediating oxidative stress effects on PI 3-kinase signaling.

Main Results:

  • The phosphoinositide 3-kinase (PI 3-kinase)/protein kinase B (PKB) pathway is a key signaling cascade activated by ROS.
  • This pathway connects oxidative stress to cellular functions such as survival and metabolism, relevant to neoplastic, metabolic, and degenerative diseases.

Conclusions:

  • The PI 3-kinase/PKB pathway is a critical mediator between oxidative stress and cellular responses in disease.
  • Understanding the regulation of PI 3-kinase signaling by systems like glutathione, thioredoxin, and phosphatases is crucial for therapeutic strategies against oxidative stress-related conditions.

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