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Updated: Aug 18, 2026

Single-molecule Imaging of Gene Regulation In vivo Using Cotranslational Activation by Cleavage (CoTrAC)
Published on: March 15, 2013
[Progress in the molecular mechanisms of nuclear coactivator PGC-1]
1Institute of Geriatrics, Ministry of Health, Beijing Hospital, Beijing 100730, China. sunl90@genetics.ac.cn
Abstract:
Peroxisome proliferators-activated receptor-gamma coactivator-1 is broadly involved in several key cellular pathways including mitochondrial biogenesis, hepatic gluconeogenesis via interacting with many transcription factors, which is highly valuable to maintain the energy balance of organisms. This review especially focuses on the recent progress in the molecular docking, histone acetylation, RNA processing basing on the structure of PGC-1 gene and amino acid sequence. Besides, the prospect of PGC-1 in applications of metabolic syndromes has been discussed also.
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