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Related Experiment Videos

BAFF augments certain Th1-associated inflammatory responses.

Andrew P R Sutherland1, Lai Guan Ng, Carrie A Fletcher

  • 1Arthritis and Asthma Research Program, Garvan Institute of Medical Research, Sydney, Australia.

Journal of Immunology (Baltimore, Md. : 1950)
|April 22, 2005
PubMed
Summary

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B cell-activating factor (BAFF) influences both T and B cell responses. Overexpressed BAFF exacerbates Th1 inflammation but protects against Th2 allergic reactions, impacting autoimmune and viral conditions.

Area of Science:

  • Immunology
  • Autoimmunity
  • Inflammation

Background:

  • B cell-activating factor (BAFF) is crucial for B cell maturation and survival.
  • BAFF overexpression in transgenic (Tg) mice leads to autoimmune disorders.
  • BAFF influences T cell function via BAFF-R binding.

Purpose of the Study:

  • To investigate the impact of BAFF on T helper 1 (Th1) and T helper 2 (Th2) mediated inflammatory responses.
  • To explore the role of BAFF in T cell-mediated inflammatory reactions using BAFF Tg mice.

Main Methods:

  • Utilized BAFF transgenic (Tg) mice to model elevated BAFF levels.
  • Assessed cutaneous delayed-type hypersensitivity (Th1 model) and allergic airway inflammation (Th2 model).
  • Measured paw swelling, inflammation, serum BAFF levels, and T cell proliferation.

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Main Results:

  • BAFF Tg mice exhibited significantly greater paw swelling and inflammation in the Th1 response.
  • Delayed-type hypersensitivity scores correlated directly with serum BAFF levels.
  • BAFF Tg mice showed protection in the Th2 model, with reduced T cell proliferation and eosinophil infiltration.

Conclusions:

  • Systemic BAFF differentially affects Th1 and Th2 responses.
  • BAFF augments T cell responses, particularly Th1-type responses.
  • Findings may be relevant to autoimmune diseases and viral infections with elevated BAFF levels.