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Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Comparison with ligation and excision

M Takano1, J Iwadare, H Ohba

  • 1Coloproctology Center, Takano Hospital, 4-2-88 Obiyama, Kumamoto 862-0924, Japan. m-takano@ku.magma.ne.jp

International Journal of Colorectal Disease
|April 22, 2005
PubMed

Insights

A new sclerosing agent, OC-108, offers a less invasive treatment for prolapsing internal hemorrhoids, showing similar prolapse disappearance rates to surgery but with fewer side effects.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Pharmacological Treatments

Background:

  • Prolapsing internal hemorrhoids are a common condition.
  • Traditional surgical treatments like ligation and excision carry risks of pain and bleeding.
  • A novel sclerosing agent, OC-108, was developed for hemorrhoid treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of OC-108 for treating prolapsing internal hemorrhoids.
  • To compare OC-108 treatment outcomes with traditional surgical interventions.

Main Methods:

  • A comparative study involving patients aged 20 years and older with prolapsing internal hemorrhoids.
  • Treatment groups included the novel sclerosing agent OC-108 and conventional surgery (ligation and excision).
  • Data collected from ten Japanese medical institutions between October 2000 and October 2002.

Main Results:

  • At 28 days, prolapse disappearance rates were comparable: 94% for OC-108 versus 99% for surgery.
  • The 1-year recurrence rate was 16% for OC-108, which is considered satisfactory given its less invasive nature, compared to 2% for surgery.
  • Patients treated with OC-108 experienced significantly lower incidences of pain and bleeding.

Conclusions:

  • OC-108 presents a viable and less invasive alternative treatment option for patients with prolapsing internal hemorrhoids.
  • The agent demonstrates comparable efficacy in prolapse resolution with improved safety profile regarding pain and bleeding.
Abstract

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