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Relationship between endothelial dysfunction and serum homocysteine in patients with coronary lesions

Zhe Chen1, Chun-sheng Li, Jian Zhang

  • 1Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020. cz8088@yahoo.com

Chinese Medical Sciences Journal = Chung-Kuo I Hsueh K'O Hsueh Tsa Chih
|April 23, 2005
PubMed

Insights

Elevated serum homocysteine (HCY) levels correlate with endothelial dysfunction and coronary artery disease markers. This suggests HCY may predict coronary lesions and indicate endothelial cell injury.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Pathophysiology

Background:

  • Vascular endothelial dysfunction is implicated in coronary artery disease (CAD).
  • Serum homocysteine (HCY) is a potential risk factor for cardiovascular events.
  • Understanding the link between HCY and endothelial markers is crucial for CAD assessment.

Purpose of the Study:

  • To investigate the relationship between serum homocysteine (HCY) levels and markers of vascular endothelial dysfunction.
  • To explore the association between HCY and coronary lesions in patients undergoing coronary angiography.

Main Methods:

  • Measured serum HCY, nitric oxide (NO), endothelin-1 (ET-1), and circulating endothelial cells (CEC) in 76 patients.
  • Categorized patients into coronary artery disease (CAD) group (stenosis ≥50%) and control group.
  • Utilized enzyme immunoassay, nitrate reductase kit, radio-immunoassay, and flow cytometry for measurements.

Main Results:

  • Patients with coronary lesions showed significantly higher HCY, ET-1, and CEC levels compared to controls (P < 0.01).
  • NO levels were significantly lower in the CAD group (P < 0.01).
  • HCY positively correlated with ET-1 and CECs, and negatively with NO/ET-1 ratio (P < 0.05).

Conclusions:

  • Elevated HCY may contribute to endothelial cell injury, linking hyperhomocysteinemia to CAD development.
  • Serum HCY can be considered a predictor for preliminary or active coronary lesions.
  • HCY is associated with key markers of endothelial dysfunction in CAD patients.
Abstract

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