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Updated: Aug 18, 2026

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Published on: June 5, 2019
Physical and psychological factors influencing heart rate variability in anorexia nervosa
1Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Japan. dsyu@cephal.med.kyushu-u.ac.jp
Objective:
The aim of this study was to determine which physical and psychological factors influence the autonomic nervous system (ANS) of patients with anorexia nervosa (AN).
Methods:
The subjects were 14 AN patients and 12 healthy controls. Beat to beat heart rate variability recorded in a supine position with a controlled respiratory rate of 15/min, was analyzed using power spectral analysis. Symptoms of anxiety and depression were assessed by State and Trait Anxiety Inventory and Zung's Self-rating Depression Scale respectively.
Results:
Anxiety had a significant negative correlation with the ANS of AN patients. The illness duration times body mass index (BMI), a measure of sustained extreme loss of weight, was also significantly associated with changes in the ANS of AN patients.
Conclusion:
Although the ANS is influenced by various factors, sustained extreme loss of weight seems to be more influential factor in AN patients.
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