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Updated: Jul 15, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
Published on: March 14, 2013
Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry
1Laboratory of Seeds Finding Technology, Eisai Co Ltd, 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. y-ishihama@hhc.eisai.co.jp
Abstract:
Current nano-scale liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) approaches in proteome research are reviewed from an analytical perspective. For comprehensive analysis of cellular proteins, analytical methods with higher resolution, sensitivity, and wider dynamic range are required. Miniaturized LC coupled with tandem mass spectrometry is currently one of the most versatile techniques. In this review, the current status of nanoLC-MS/MS systems as well as data management systems is addressed. In addition, the future prospects for complete proteomics are discussed.
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