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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Amniotic fluid analysis. Part I: Rapid markers in the prediction of intra-amniotic infection]

Barbara Królak-Olejnik1, Wojciech Kaźmierczak, Igor Olejnik

  • 1Katedra i Klinika Perinatologii i Ginekologii SlAM.

Ginekologia Polska
|April 23, 2005
PubMed

Insights

Intraamniotic infection is a key cause of preterm delivery. This study evaluated diagnostic tests like Gram stain and white blood cell count to predict infection and preterm birth risks.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatal Health

Context:

  • Intraamniotic infection is a significant cause of preterm birth.
  • Amniocentesis is proposed for identifying patients at risk of infectious morbidity.
  • Rapid diagnostic methods for amniotic cavity bacterial colonization are under investigation.

Purpose:

  • To evaluate the diagnostic index of Gram stain, white blood cell count, glucose level, and lactate dehydrogenase (LDH) activity.
  • To assess the predictive value of these tests for positive amniotic fluid culture, preterm delivery, clinical infection, and neonatal sepsis.

Summary:

  • The study assessed the utility of Gram stain, WBC count, glucose, and LDH in amniotic fluid for predicting intraamniotic infection and adverse outcomes.
  • Results indicate the diagnostic value of these markers in identifying patients at risk for preterm delivery and neonatal complications.

Impact:

  • Findings contribute to understanding rapid diagnostic markers for intraamniotic infection.
  • Aims to improve the prediction of preterm delivery and associated neonatal sepsis through early detection of infection.

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