Jove
Visualize
Contact Us

Related Experiment Videos

Opioid abuse and cognitive performance.

Miriam Z Mintzer1, Marc L Copersino, Maxine L Stitzer

  • 1Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA. mmintzer@jhmi.edu

Drug and Alcohol Dependence
|April 23, 2005
PubMed
Summary

Methadone maintenance may worsen cognitive deficits beyond those from long-term opioid abuse. Abstinence may allow for some functional recovery, but further research is needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exposure to Bupropion-SR vs. Placebo is associated with reductions in smoking among persons receiving methadone with no stated interest in smoking cessation.

Addictive behaviors·2024
Same author

Clinical translation of expert-endorsed cognitive rehabilitation interventions for substance use disorders.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2024
Same author

Society for Research on Nicotine and Tobacco as an Outgrowth of the 1988 Surgeon General's Report on Nicotine Addiction: Reflections of the Early Presidents.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2023
Same author

A Pilot Study of Adjunctive Group Therapy to Enhance Coping With Cognitive Challenges and Support Cognitive Health After Electroconvulsive Therapy.

The journal of ECT·2023
Same author

Factors related to substance use treatment attendance after peer recovery coach intervention in the emergency department.

Drug and alcohol dependence reports·2023
Same author

Cognitive training and remediation interventions for substance use disorders: a Delphi consensus study.

Addiction (Abingdon, England)·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Medicine

Background:

  • Opioid abuse is linked to cognitive deficits.
  • Methadone maintenance is a common treatment for opioid dependence.
  • Previous research suggests methadone maintenance patients (MMP) may experience performance impairments.

Purpose of the Study:

  • To investigate whether methadone maintenance itself contributes to performance impairment, distinct from long-term opioid abuse.
  • To compare cognitive performance between abstinent former opioid abusers, current MMP, and non-drug abusing controls.

Main Methods:

  • Compared a group of 20 abstinent former opioid abusers to previously studied groups of 18 MMP and 21 controls.
  • Utilized the same performance testing battery for all groups.

Related Experiment Videos

  • Ensured demographic and drug history similarity between abstinent abusers and MMP.

    • Main Results:

    • Abstinent abusers' performance fell between MMP and controls on many measures.
    • This suggests methadone maintenance may be associated with additional impairment beyond long-term abuse.
    • Some recovery of functioning may occur with abstinence.

    Conclusions:

    • Methadone maintenance may impose additional cognitive burdens.
    • Abstinence shows potential for functional recovery.
    • Further research is needed to understand impairment factors and clinical significance in MMP.