Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased nuchal translucency with normal karyotype.

Athena P Souka1, Constantin S Von Kaisenberg, Jonathan A Hyett

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College, London University, London, UK.

American Journal of Obstetrics and Gynecology
|April 23, 2005
PubMed
Summary

Increased fetal nuchal translucency (NT) is linked to chromosomal issues. However, without aneuploidy, NT measurements above 3.5 mm indicate higher risks for adverse perinatal outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Compound Heterozygous CFAP53 Variants in a Fetus With Situs Inversus Totalis: A Case Report.

Cureus·2026
Same author

Transthoracic echocardiography Guidelines of the German Society for Ultrasound in Medicine, German Cardiac Society, German Society of Anesthesiology and Intensive Care Medicine, German Society of Internal Medicine, Professional Association of German Internists, and the German Association of Cardiologists in Private Practice (Association of Scientific Medical Societies in Germany, S2k LL85-004, 9/1/20.

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2026
Same author

S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study.

PloS one·2026
Same author

Management of preterm prelabor rupture of membranes based on the amniocentesis information.

American journal of obstetrics and gynecology·2025
Same author

Update on: Firsttrimester Diagnosis and Therapy @ 11 - 13 <sup>+6</sup> weeks' gestation : Amendment to the Guideline of DEGUM, ÖGUM, SGUMGG, DGGG, ÖGG, Gynecologie Suisse, DGPM, DGPGM, BVF, ACHSE (AWMF S2e LL085-002 1.1.2024) (https://register.awmf.org/de/leitlinien/detail/085-002).

Geburtshilfe und Frauenheilkunde·2025
Same author

The nitric oxide donor pentaerythritol tetranitrate lowers hypertension and angiogenic imbalance in pregnancies with impaired uterine perfusion-a secondary analysis of a randomized trial.

American journal of obstetrics and gynecology·2025

Area of Science:

  • Prenatal diagnosis
  • Fetal medicine
  • Genetics

Background:

  • Increased fetal nuchal translucency (NT) thickness during early gestation (11-14 weeks) is a recognized indicator of chromosomal abnormalities, such as trisomy 21.
  • Nuchal thickening, even without aneuploidy, is clinically significant due to its association with adverse perinatal outcomes stemming from various fetal anomalies.

Purpose of the Study:

  • To analyze the clinical relevance of fetal nuchal translucency (NT) measurements in predicting perinatal outcomes.
  • To determine the NT threshold associated with increased risk of adverse outcomes in the absence of aneuploidy.

Main Methods:

  • Retrospective analysis of NT measurements in fetuses between 11 and 14 weeks' gestation.
  • Correlation of NT thickness with chromosomal status and perinatal outcomes.

Related Experiment Videos

  • Assessment of risk based on NT measurement thresholds.

    • Main Results:

    • Aneuploidy is a common association with increased NT thickness.
    • In the absence of aneuploidy, a statistically significant increase in perinatal risk is observed when NT measurements exceed 3.5 mm (99th percentile).
    • The risk of adverse outcomes increases exponentially with greater NT measurements.

    Conclusions:

    • Fetal NT measurement is a valuable screening tool for chromosomal abnormalities and adverse perinatal outcomes.
    • NT measurements above 3.5 mm, even without aneuploidy, warrant close monitoring for potential fetal malformations and adverse outcomes.
    • A normal mid-gestation ultrasound (20-22 weeks) following initial NT screening significantly reduces the risk of adverse perinatal outcomes and developmental delay.