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Covariate detection in population pharmacokinetics using partially linear mixed effects models.

Peter L Bonate1

  • 1Genzyme Corp., San Antonio, Texas 78229, USA. peter.bonate@ilexonc.com

Pharmaceutical Research
|April 23, 2005
PubMed
Summary

Partially linear mixed effects models (PLMEMs) and nonlinear mixed effects modeling (NONMEM) using the likelihood ratio test (LRT) show comparable power and Type I error rates for covariate detection. PLMEMs provide a valid alternative to NONMEM for covariate screening.

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