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Updated: Aug 18, 2026
Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease
Stefan K Gölder1, Andreas G Schreyer, Esther Endlicher
1Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany.
Background And Aims:
Small bowel MR enteroclysis and wireless capsule endoscopy (WCE) are new diagnostic tools for the investigation of the small bowel. The aim of this study was to compare the diagnostic yield of WCE with MR enteroclysis in the detection of small bowel pathologies.
Methods:
A total of 36 patients were included in the study. Indications for imaging of the small bowel were proven or suspected small bowel Crohn's disease (CD; n=18), obscure gastrointestinal (GI) bleeding (n=14) and tumour surveillance (n=4).
Results:
In patients with Crohn's disease WCE detected significantly more inflammatory lesions in the first two segments of the small bowel compared with MR enteroclysis (12 patients vs. 1 patient, p=0.016). In 5 out of 14 (36%) patients with GI bleeding, angiodysplasia was detected as a possible bleeding source. Three of these patients had active bleeding sites detected by WCE. One patient had scattered inflammation of the mucosa. MR enteroclysis did not reveal any intestinal abnormalities in this patient group. MR enteroclysis provided extraintestinal pathologies in 10 out of 36 (28%) patients.
Conclusion:
In patients with Crohn's disease WCE revealed significantly more inflammatory lesions in the proximal and middle part of the small bowel in comparison to MR enteroclysis, whereas in patients with obscure GI bleeding WCE was superior to MR enteroclysis.
Insights
Wireless capsule endoscopy (WCE) is more effective than MR enteroclysis for detecting small bowel Crohn's disease and obscure GI bleeding. WCE identified more inflammatory lesions in Crohn's patients and bleeding sources in GI bleeding patients.
Area of Science:
- Gastroenterology
- Diagnostic Imaging
- Endoscopy
Background:
- Small bowel pathologies require advanced diagnostic tools.
- MR enteroclysis and wireless capsule endoscopy (WCE) are emerging methods for small bowel investigation.
Purpose of the Study:
- To compare the diagnostic yield of WCE and MR enteroclysis.
- To evaluate their effectiveness in detecting small bowel pathologies.
Main Methods:
- 36 patients with suspected small bowel Crohn's disease, obscure GI bleeding, or tumor surveillance were included.
- Diagnostic yield of WCE and MR enteroclysis was compared.
Main Results:
- WCE detected significantly more inflammatory lesions in Crohn's disease patients compared to MR enteroclysis (12 vs. 1).
- In obscure GI bleeding cases, WCE identified angiodysplasia in 36% of patients, while MR enteroclysis found no abnormalities.
- MR enteroclysis identified extraintestinal pathologies in 28% of patients.
Conclusions:
- WCE is superior to MR enteroclysis for detecting inflammatory lesions in the proximal and middle small bowel in Crohn's disease patients.
- WCE demonstrated higher efficacy than MR enteroclysis in diagnosing obscure GI bleeding.
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