Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Echocardiographic alterations in systemic sclerosis: a longitudinal study.

Stefania Maione1, Giovanna Cuomo, Anna Giunta

  • 1Department of Clinical Medicine, Cardiovascular and Immunological Science, University of Naples Federico II, Italy. smaione@unina.it

Seminars in Arthritis and Rheumatism
|April 23, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical profile of systemic sclerosis without a 'scleroderma pattern' at nailfold capillaroscopy: results from the multicenter SPRING registry of the Italian Society of Rheumatology.

Journal of translational autoimmunity·2026
Same author

Safety and effectiveness of tocilizumab in systemic sclerosis: a multicentre French-Italian study.

RMD open·2026
Same author

Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.

RMD open·2026
Same author

Integrating multiple sensory modalities during dyadic interactions drives self-other distinction at the behavioral and electrocortical level.

iScience·2026
Same author

The clinical phenotype of anti-Th/To+ patients in systemic sclerosis: a case-control study within the European Scleroderma Trials and Research cohort.

Therapeutic advances in musculoskeletal disease·2026
Same author

Point-of-care ultrasound for fractures of the limbs and the skull in children: breaking down the evidence.

Pediatric radiology·2026

Systemic sclerosis (SSc) patients commonly develop left ventricular (LV) diastolic dysfunction, a progressive condition that precedes anatomical heart changes and indicates primary myocardial involvement.

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease.
  • Cardiac involvement is a significant cause of morbidity and mortality in SSc.
  • Understanding the progression of cardiac alterations in SSc is crucial for patient management.

Purpose of the Study:

  • To investigate the longitudinal evolution of cardiac alterations in patients with systemic sclerosis (SSc).
  • To determine the prevalence and progression of left ventricular (LV) diastolic dysfunction in SSc.
  • To assess the relationship between diastolic dysfunction and myocardial remodeling in SSc.

Main Methods:

  • Retrospective analysis of echocardiographic and echo-Doppler data from 77 SSc patients.
  • Follow-up assessment at 65 +/- 36 months.

Related Experiment Videos

  • Comparison with 45 age- and sex-matched healthy controls.

    • Main Results:

    • Baseline LV diastolic dysfunction (inverted E/A ratio) was significantly more prevalent in SSc patients (23/77) than controls (1/45).
    • Over the follow-up period, LV diastolic function worsened in 6 additional SSc patients.
    • Significant changes in LV filling parameters and left atrial dimension indicated progressive cardiac involvement, independent of other causes.

    Conclusions:

    • LV diastolic dysfunction is highly prevalent in SSc and suggests primary myocardial involvement.
    • Long-term follow-up reveals progressive LV filling dysfunction in SSc.
    • Impaired LV filling precedes anatomical LV remodeling in systemic sclerosis.