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Benperidol for schizophrenia.

S Leucht1, B Hartung

  • 1Klinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar der TU-München, Ismaningerstr. 22, München, Germany, 81675. Stefan.Leucht@lrz.tu-muenchen.de

The Cochrane Database of Systematic Reviews
|April 23, 2005
PubMed
Summary
This summary is machine-generated.

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Limited data exists for benperidol, an antipsychotic drug. One trial suggests it may be less effective than perphenazine for schizophrenia, but more research is needed to confirm its clinical effects and safety.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Research

Background:

  • Benperidol is a high-potency butyrophenone antipsychotic used since 1966, known for potent D2 receptor blockade.
  • Associated with a high risk of extrapyramidal side effects, its unique profile may benefit specific schizophrenia subgroups.
  • Available in several European countries, including Germany, the Netherlands, and the UK.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of benperidol in treating schizophrenia and schizophrenia-like psychoses.
  • To synthesize evidence from randomized controlled trials (RCTs) on benperidol's use.

Main Methods:

  • A systematic search of the Cochrane Schizophrenia Group's register (up to November 2004) was conducted.
  • Included only randomized controlled trials comparing benperidol with other treatments for schizophrenia or similar psychoses.

Related Experiment Videos

  • Data extraction and quality assessment were performed, with a 50% loss to follow-up exclusion criterion.

    • Main Results:

    • The review identified only one unpublished, low-quality randomized controlled trial with 40 participants.
    • Benperidol was found to be inferior to perphenazine in improving the global state (RR 8.0, 95% CI 2.1 to 30).
    • Due to poor reporting, the reliability of these findings is questionable, and other outcomes could not be assessed.

    Conclusions:

    • Insufficient randomized trial data currently exists to determine the clinical effects and safety of benperidol.
    • Benperidol warrants further investigation and research interest due to its distinct pharmacological profile.