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Related Experiment Videos

Vitamin E supplementation in pregnancy.

A Rumbold1, C A Crowther

  • 1Department of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, Australia, 5006. alice.rumbold@adelaide.edu.au

The Cochrane Database of Systematic Reviews
|April 23, 2005
PubMed
Summary
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Limited evidence suggests vitamin E supplementation during pregnancy may reduce pre-eclampsia risk. However, more research is needed to confirm vitamin E

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Clinical Trials

Background:

  • Oxidative stress during pregnancy can lead to complications like pre-eclampsia.
  • Vitamin E, an antioxidant, is being investigated for its potential to mitigate these risks.
  • Further evaluation of vitamin E's efficacy and safety in pregnancy is warranted.

Purpose of the Study:

  • To assess the impact of vitamin E supplementation on pregnancy outcomes.
  • To evaluate adverse events, side-effects, and healthcare utilization associated with vitamin E.
  • To determine if vitamin E, alone or with other supplements, affects maternal and infant health.

Main Methods:

  • Systematic review of randomized and quasi-randomized controlled trials.
  • Searched multiple databases including Cochrane, MEDLINE, Current Contents, and EMBASE.

Related Experiment Videos

  • Included trials involving pregnant women supplemented with vitamin E, excluding multivitamins.

    • Main Results:

    • Four trials with 566 women were included, primarily assessing vitamin E with other supplements.
    • No significant differences were observed for stillbirth, neonatal death, perinatal death, preterm birth, or intrauterine growth restriction.
    • A potential reduction in pre-eclampsia risk was suggested by fixed-effect models but not confirmed by random-effects models.

    Conclusions:

    • Current data are insufficient to establish the benefits of vitamin E supplementation during pregnancy.
    • More high-quality trials are needed to determine the efficacy and safety of vitamin E.
    • The role of vitamin E in preventing pregnancy complications remains uncertain.