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Related Experiment Videos

Vitamin supplementation for preventing miscarriage.

A Rumbold1, P Middleton, C A Crowther

  • 1Department of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, Australia, 5006. alice.rumbold@adelaide.edu.au

The Cochrane Database of Systematic Reviews
|April 23, 2005
PubMed
Summary
This summary is machine-generated.

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Vitamin supplementation before or during early pregnancy does not prevent miscarriage or stillbirth. However, it may reduce the risk of pre-eclampsia and increase the likelihood of multiple pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Reproductive Health

Background:

  • Miscarriage is a common pregnancy complication linked to various factors, including poor vitamin intake.
  • Vitamin supplementation during preconception or early pregnancy is explored as a potential miscarriage prevention strategy.

Purpose of the Study:

  • To evaluate the effectiveness and safety of vitamin supplementation in reducing spontaneous miscarriage risk.
  • To assess the impact of vitamin supplementation on maternal and fetal/infant adverse outcomes.

Main Methods:

  • Systematic review and meta-analysis of randomized and quasi-randomized controlled trials.
  • Searched multiple databases including Cochrane, MEDLINE, Current Contents, and EMBASE up to May 2003.
  • Included trials comparing vitamin supplementation with placebo, other vitamins, or no intervention prior to 20 weeks' gestation.

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Main Results:

  • Seventeen trials involving over 35,000 women were analyzed.
  • No significant difference in total fetal loss, miscarriage, or stillbirth rates between vitamin users and controls.
  • Vitamin supplementation was associated with a reduced risk of pre-eclampsia and an increased likelihood of multiple pregnancies.

Conclusions:

  • Vitamin supplementation before or during early pregnancy does not prevent miscarriage or stillbirth.
  • Women taking vitamin supplements may experience a lower incidence of pre-eclampsia.
  • Increased rates of multiple pregnancies were observed in women taking vitamin supplements.