Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glial nitric oxide and ischemia.

Claire L Gibson1, Teresa C Coughlan1, Sean P Murphy1

  • 1Institute of Cell Signaling, Medical School, University of Nottingham, Nottingham, United Kingdom.

Glia
|April 23, 2005
PubMed
Summary

Cerebral ischemia increases nitric oxide (NO) production. NO

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice.

Scientific reports·2026
Same author

Diameter, height, and volume as macroscopic predictors of photocarcinogenesis in UV-induced SKH1 papules.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

A Systematic Review and Meta-Analysis Examining Sex Differences in Mental Rotation Ability.

Quarterly journal of experimental psychology (2006)·2026
Same author

Acute UV response of early erythema and late edema in SKH1 mice.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

Preclinical Ischemic Stroke Multicenter Trials (PRISM) Collective Statement: Opportunities, Challenges, and Recommendations for a New Era.

Stroke·2025
Same author

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2025

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Cerebral ischemia triggers increased nitric oxide (NO) production.
  • NO's role in ischemic pathology is complex, with both detrimental and beneficial effects.
  • The impact of NO is context-dependent, varying with cell type, quantity, and oxidation products.

Purpose of the Study:

  • To elucidate the role of nitric oxide (NO) in ischemic brain injury.
  • To understand how microglial and astrocyte-derived NO contribute to neuropathology.
  • To inform the development of targeted therapeutics for brain injury.

Main Methods:

  • Enzyme activity assays to measure nitric oxide synthase (NOS) expression.
  • Measurement of nitric oxide and its metabolites.
  • Cellular and animal models of cerebral ischemia.

Main Results:

  • Increased nitric oxide synthase (NOS) activity observed in response to cerebral ischemia.
  • Nitric oxide production confirmed from both resident (microglia, astrocytes) and infiltrating cells.
  • Evidence suggests both damaging and protective roles of nitric oxide depending on production site and levels.

Conclusions:

  • Nitric oxide plays a dual role in cerebral ischemia.
  • Targeting nitric oxide pathways in microglia and astrocytes may offer therapeutic benefits.
  • Further research is needed to precisely modulate NO for treating brain injury.

Related Experiment Videos