Related Experiment Video
Updated: Aug 7, 2026

Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
[Gonadotropins and ovarian cancer]
Ewa Nowak-Markwitz1, Anna Jankowska, Marek Spaczyński
1Klinika Onkologii Ginekologicznej, AM im Karola Marcinkowskiego w Poznaniu.
Abstract:
The ovary is a tissue, which is sensitive to gonadotropins. Gonadotropins receptors are present in the epithelium and stroma of the ovary. Data from epidemiological study clearly shows, that development of tumor is correlated with morphological and biochemical processes taking place in the gonad. The role of gonadotropins, as well as the role of their receptors in the proliferation of the ovarian tissue was shown. Further research is needed to explain the molecular mechanism of gonadotropin activity in ovarian tissue, however the important role of gonadotropins in the pathology of ovarian tissue is already well established.
Related Concept Videos
Oogenesis
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Ovarian Cycle
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

