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Updated: Aug 18, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
[Report of two cases of bladder and prostate oat cell tumors]
Juan José Ballesteros Sampol1, Josep Lloreta Trull, Cristina Ballesteros Monzó
1Servicios de Urología y Patología del Hospital de la Esperanza, Barcelona, España. 18190@imas.imim.es
Objectives:
To report two cases of bladder and prostate oat cell tumors with bad outcome, in accordance to the bibliographic review.
Methods:
The case in the bladder was associated with squamous differentiation and adenocarcinoma. Radical treatment followed by adjuvant chemotherapy did not stop the fatal outcome which ended 13 months later in acute septicemia having developed multiple metastases. The case in the prostate presented as oliguria-anuria and bilateral hydronephrosis which required the placement of a nephrostomy tube in an emergency basis. Once diagnosis was achieved the extemal urinary diversion was converted to intemal to improve patient's comfort. There was no response to systemic chemotherapy and the patient died 4 months after diagnosis.
Conclusions:
These cases add to the rare presence of this pathology in the bibliography. In our country, 15 cases have been confirmed in the bladder and 5 in the prostate; around the world, 150 and 59 respectively. Although there is a certain tendency to think that radical treatment and chemotherapy is the least bad of the options, some consequences of conservative attitudes offer similar results, mainly when preserving the bladder.

