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Updated: Aug 18, 2026

In vitro Measurements of Tracheal Constriction Using Mice
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Published on: June 25, 2012

Prolonged exposure to NT-3 attenuates cholinergic nerve-mediated contractions in cultured murine airways

Ofir Bachar1, Mikael Adner, Rolf Uddman

  • 1Department of Otorhinolaryngology, Laboratory of Clinical Experimental Allergy Research, Malmö University Hospital, SE-20502 Malmö, Sweden. Ofir.Bachar@oron.mas.lu.se

Respiratory Physiology & Neurobiology
|April 26, 2005
PubMed

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Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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