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Related Experiment Videos

The Dutch algorithm for allocation in living donor kidney exchange.

K M Keizer1, M de Klerk, B J J M Haase-Kromwijk

  • 1Dutch Transplantation Foundation, Erasmus Medical Center, Rotterdam, The Netherlands. k.keizer@transplantatiestiching.nl

Transplantation Proceedings
|April 26, 2005
PubMed
Summary

Kidney transplantation faces donor shortages, leading to paired donor exchange programs. An allocation algorithm prioritizes recipients with the lowest match probability, improving access to living donor kidneys.

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Transplantation proceedings·2018

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Medical informatics

Background:

  • Shortage of deceased donor kidneys necessitates alternative strategies for kidney transplantation.
  • Living donor kidney transplantation is limited by ABO blood group incompatibility and immunological factors.
  • Crossover, or paired donor exchange, offers a solution for incompatible donor-recipient pairs.

Purpose of the Study:

  • To describe the joint protocol for crossover kidney transplantation developed by Dutch centers.
  • To introduce the allocation algorithm developed by the Dutch Transplantation Foundation for matching pairs.
  • To evaluate the effectiveness of the algorithm in facilitating compatible kidney exchanges.

Main Methods:

  • Implementation of a joint protocol across seven Dutch kidney transplantation centers.

Related Experiment Videos

  • Development of a computer program by the Dutch Transplantation Foundation for matching donor-recipient pairs.
  • An allocation algorithm calculating match probability (MP) based on %PRA, ABO compatibility, and HLA unacceptables.

    • Main Results:

    • Three crossover kidney transplantation matches have been performed to date.
    • A total of 53 donor-recipient pairs participated from all seven Dutch centers.
    • Compatible donor-recipient pairs were identified for 22 of the participating pairs.

    Conclusions:

    • The developed allocation algorithm effectively identifies compatible donor-recipient pairs for exchange.
    • The paired donor exchange program demonstrates potential in increasing access to kidney transplantation.
    • Further implementation and analysis are needed to optimize the program's impact.