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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jul 20, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

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Published on: July 15, 2015

Warm ischemic time during laparoscopic live donor nephrectomy: effects on graft function.

R E Soulsby1, L J Evans, K M Rigg

  • 1Nottingham Kidney Transplant Centre, Nottingham City Hospital NHS Trust, Nottingham, UK.

Transplantation Proceedings
|April 26, 2005
PubMed
Summary

Warm ischemia time (WIT) during laparoscopic live donor nephrectomy (LDN) did not impact short-term or long-term kidney graft outcomes. However, prolonged WIT may be linked to a higher rate of acute rejection episodes post-transplant.

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Minimally Invasive Surgery

Background:

  • Laparoscopic live donor nephrectomy (LDN) is a standard alternative to open surgery.
  • The impact of prolonged warm ischemia time (WIT) on kidney graft outcomes after LDN requires further investigation.

Purpose of the Study:

  • To analyze the effects of WIT duration on short-term and long-term graft outcomes following LDN.

Main Methods:

  • Retrospective analysis of LDN procedures.
  • Assessment of WIT effects on delayed graft function, serum creatinine levels, acute rejection rates, and graft survival.
  • Comparison of outcomes based on WIT duration: <=3 min vs >3 min, and <5 min, 5-10 min, >10 min.

Main Results:

  • WIT ranged from 1 to 15 minutes, influenced by the learning curve and technical challenges.
  • Prolonged WIT did not affect early graft function or serum creatinine decline within the first 3 months.
  • An increased rate of acute rejection may be associated with longer WIT, though changes in Delta creatinine were unaffected.

Conclusions:

  • Warm ischemia time (WIT) during laparoscopic live donor nephrectomy (LDN) does not influence short-term or long-term kidney graft outcomes.
  • The study suggests WIT may correlate with acute rejection rates, warranting further research.