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Updated: Aug 18, 2026
Human Pancreatic Islet Isolation: Part II: Purification and Culture of Human Islets
Published on: May 26, 2009
University of Wisconsin solution versus Celsior solution in clinical pancreas transplantation
U Boggi1, S Signori, F Vistoli
1Centro Regionale di Riferimento per la Cura delle Malattie del Pancreas, University of Pisa, Pisa, Italy.
Introduction:
This study compared the safety and efficacy of University of Wisconsin solution (UW) and Celsior solution (C) in pancreas transplantation (PTx).
Methods:
A retrospective review of 154 PTx performed over a 61-month period included 77 grafts preserved with UW and 77 with C. The two groups were comparable for both donor and recipient characteristics.
Results:
After a mean cold ischemia time of 624 minutes (range 360 to 945 minutes) for UW versus 672 minutes (range 415 to 1005 minutes) for C (P = NS), no primary endocrine nonfunction occurred. Delayed endocrine function was diagnosed in two grafts in the UW group (2.6%) versus none in the C group (P = NS). After a minimum follow-up of 4 months (mean 26.5 +/- 15.2 months), 22 recipients (UW = 11 vs C = 11; P = NS) required relaparotomy. Overall, 18 pancreata were lost due to either patient death with functioning graft (UW = 4 vs C = 1; P = NS) or graft loss due to other reasons (UW = 8 vs C = 5; P = NS). Actuarial 1- and 5-year patient survival rates were 93.5% and 86.8% for UW compared with 98.7% and 98.7% for C (P = .04). Actuarial graft survival rates at the same times were 88.3% and 75.0% for UW compared with 90.4% and 90.4% for C (P = NS).
Conclusions:
Within the range of cold ischemia times reported in this study, UW and C show similar safety and efficacy profiles for PTx.
