Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New exchanges in eph-dependent growth cone dynamics.

Keith K Murai1, Elena B Pasquale

  • 1Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.

Neuron
|April 26, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role" [BBA Mol. Cell Res. 1873 (2026) 120081].

Biochimica et biophysica acta. Molecular cell research·2026
Same author

Automation of high-throughput workflow for arrayed CRISPR activation library screening.

bioRxiv : the preprint server for biology·2025
Same author

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.

Biochimica et biophysica acta. Molecular cell research·2025
Same author

Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum.

Frontiers in neuroanatomy·2025
Same author

Single-cell omics and heterogeneity of neuroglial cells.

Handbook of clinical neurology·2025
Same author

An Astrocyte Transplantation Method to Investigate Astrocyte Development and Diversity in the Central Nervous System (CNS).

Methods in molecular biology (Clifton, N.J.)·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Eph receptor tyrosine kinases and ephrin ligands guide developing neurons. These receptors control growth cone dynamics by regulating Rho GTPases, crucial for axon pathfinding and neural circuit formation.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Eph receptor tyrosine kinases (RTKs) and ephrin ligands are critical for neural development.
  • They influence cell morphology by regulating the actin cytoskeleton and plasma membrane dynamics.
  • Rho family GTPases are key mediators of these cellular responses.

Discussion:

  • Two studies investigate the mechanism by which Eph receptors modulate growth cone dynamics.
  • Focus is on the recruitment of guanine nucleotide exchange factors (GEFs) for Rho GTPases.
  • This recruitment links Eph receptor signaling to cytoskeletal rearrangements.

Key Insights:

  • Eph receptors directly influence the activity of GEFs that control Rho GTPases.
  • This signaling pathway is essential for precise axon pathfinding.

Related Experiment Videos

  • Understanding this mechanism provides insight into neural circuit formation.

    • Outlook:

    • Further research can explore the specific GEFs involved and their downstream effectors.
    • This knowledge may lead to therapeutic strategies for neurological disorders involving axon guidance defects.
    • Investigating Eph-ephrin signaling in other developmental contexts is warranted.