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Primary progressive aphasia: a review.

Murray Grossman1, Sharon Ash

  • 1Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104-4283, USA. mgrossma@mail.med.upenn.edu

Neurocase
|April 26, 2005
PubMed
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This review distinguishes primary progressive aphasia (PPA) into progressive non-fluent aphasia (PNFA) and semantic dementia (SD) based on clinical and imaging data. Further subdivision within these PPA subgroups is not yet supported by current evidence.

Area of Science:

  • Neurology
  • Linguistics
  • Neuroimaging

Background:

  • Primary progressive aphasia (PPA) is a neurodegenerative disorder affecting language.
  • PPA presents with distinct clinical and imaging profiles.

Purpose of the Study:

  • To review clinical and imaging features of PPA.
  • To investigate subgrouping of PPA into progressive non-fluent aphasia (PNFA) and semantic dementia (SD).
  • To assess the potential for further subdivision within PNFA and SD.

Main Methods:

  • Review of clinical linguistic profiles.
  • Analysis of neuroimaging studies.
  • Comparison of features within PNFA and SD subgroups.

Main Results:

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  • Consistent evidence supports PNFA and SD as distinct PPA subgroups.
  • Clinical and imaging data align with this distinction.
  • Current evidence is insufficient for further subgroup discrimination within PNFA or SD.

    • Conclusions:

    • PNFA and SD are well-defined subgroups of PPA.
    • Further research is needed to explore finer-grained syndromes and their neural bases.
    • Understanding these distinctions is crucial for language organization research.