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Late adverse reactions to nonionic contrast media
1Department of Radiology, Obihiro Kousei Hospital, Japan.
Radiology
|June 1, 1992
Summary
Late adverse reactions to nonionic contrast media, occurring within two days after computed tomography (CT), affect 8.0% of patients. While not life-threatening, these reactions like headache and rash are common and require awareness.
Area of Science:
- Radiology
- Pharmacovigilance
- Medical Imaging
Background:
- Adverse reactions to contrast media can occur immediately or be delayed.
- Nonionic contrast media are widely used in computed tomography (CT) scans.
- Understanding the incidence and characteristics of late reactions is crucial for patient safety.
Purpose of the Study:
- To investigate the incidence and nature of late adverse reactions following nonionic contrast media administration in CT.
- To identify patient factors associated with an increased risk of late reactions.
Main Methods:
- Prospective study design.
- Inclusion of 2,382 patients undergoing CT with nonionic contrast media.
- Definition of late reactions as events occurring between 30 minutes and 2 days post-administration.
Main Results:
- The overall rate of late adverse reactions was 8.0% (165/2,052), exceeding the rate of immediate reactions (3.8%).
- Headache and rash were the most common late reactions.
- Risk factors for late reactions included female sex, younger age, and a history of allergies.
Conclusions:
- Late adverse reactions to nonionic contrast media are common, though generally not life-threatening.
- Radiologists and referring physicians must be aware of these reactions.
- Patient education regarding potential late reactions is important.