[The morphology of hemostasis failure in gliosal brain tumors]

A retrospective study was conducted into 37 brains of patients, who had died of Grade 2-4 glioma. For assessment of morphological signs of hemorheological failure, microcirculation was checked by H & E, Klüver-Barrera, and Goldner staining as well as by staining for fibrin, using a modified technique according to Zerbino and Lukasewitsh. Microthrombosis was recorded from 30 in the above 37 brains, all of them related to patients with Grade 3 glioma and glioblastoma. Fibrin thrombi represented the predominant variant of microthrombosis. They exhibited differentiated characteristics depending on their localisation in the central and the peripheral regions of the tumour or in surrounding brain tissue. Also included in the study were rates of vascular proliferation and types of necrosis as well as relations between these and microthrombi. The role played by microthrombi in such cases of glial tumours is discussed in some detail.