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[Usefulness of 2 coproparasitological methods and their utilization in an antigiardiasis therapeutic trial]
Daimary Mendoza1, Fidel Angel Núñez, Angel Arturo Escobedo
1Instituto de Medicina Tropical "Pedro Kouri", Ciudad de La Habana, Cuba. ciipk@ipk.sld.cu
Insights
Ritchie
Area of Science:
- Medical Parasitology
- Pediatric Infectious Diseases
Background:
- Intestinal protozoan infections are common in young children.
- Accurate diagnosis and effective treatment are crucial for public health.
Purpose of the Study:
- To compare diagnostic methods for intestinal protozoa.
- To evaluate tinidazole and albendazole for Giardia lamblia treatment.
Main Methods:
- A study involving 456 children aged 1-5 years.
- Compared direct examination with Ritchie's concentration technique for protozoa diagnosis.
- Conducted a therapeutic trial using tinidazole versus albendazole for Giardia lamblia infections.
Main Results:
- Ritchie's technique showed higher diagnostic sensitivity for Giardia lamblia, Entamoeba histolytica/dispar, and Cyclospora cayetanensis.
- Serial sample examination was significantly more sensitive than single sample analysis (p < 0.01).
- Tinidazole achieved a significantly higher cure rate (72%) compared to albendazole (334.6%) for Giardia lamblia infections (p < 0.01).
Conclusions:
- Ritchie's concentration technique is superior to direct examination for diagnosing intestinal protozoa.
- Serial coproparasitological examinations enhance diagnostic accuracy.
- Tinidazole is more effective than albendazole in treating Giardia lamblia infections in children.
Abstract:
A study of 456 children aged 1-5 from 4 day care centers of San Miguel del Padron municipality was conducted in 1998, to evaluate the diagnosis of Giardia lamblia and other intestinal protozoa by using comparatively the coproparasitological diagnostic methods of direct examination and Ritchie's concentration technique or formol-ether. Besides, a therapeutical trial was developed with tinidazole and albendazole for treating the infection caused by G lamblia. Ritchie's concentration technique was more effective than the microscopic direct examination for diagnosing Giardia lamblia, Entamoeba histolytical/Entamoeba dispar and Cyclospora cayetanensis. It was demonstratyed that the serial examination was more sensitive than the analysis of just one sample (p< 0.01). On the other hand, tinidazole proved to be more efficient than albendazole to treat the infection produced by G. lamblia, with a greater cure percentage (72 % vs. 334.6%), (p < 0.01).
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