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Updated: Aug 18, 2026
A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum
Published on: April 10, 2018
[Detection of lymphoproliferative response in monkeys innoculated with dengue 4 virus]
Gissel García1, Mailing Alvarez, Elaine Santana
1Instituto de Medicina Tropical "Pedro Kouni", Autopista Novia del Mediodía, km 6 1/2 La Lisa, Apartado Postal 601. Marianao 13, Ciudad de La Habana, Cuba. ciipk@ipk.sld.cu
Abstract:
A group of 6 Cynomolgus monkeys was immunized with dengue 4 virus (H247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. A proliferative response predominantly of the specific serotype and some cross reactivity were detected. These results showed a behavior of primates similar in some extent to that of human beings and mice regarding the specific serotype and cross serotype response to dengue virus.
