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[Obesity and mortality. Italian epidemiologic data].

A Menotti1, G C Descovich, M Lanti

  • 1Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Roma.

Recenti Progressi in Medicina
|March 1, 1992
PubMed
Summary

Obesity indicators like body mass index (BMI) show an inverted U-shaped link to mortality risk. This relationship, observed in Italian studies, suggests optimal BMI ranges for lower mortality, though nuances exist for specific demographics.

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Area of Science:

  • Epidemiology
  • Public Health
  • Biostatistics

Context:

  • Analysis of obesity indicators in Italian populations.
  • Utilized data from three distinct epidemiological studies: Seven Countries Study, Brisighella study, and NFR study.
  • Involved a significant participant pool with extended follow-up periods.

Purpose:

  • To investigate the relationship between obesity indicators (BMI, skinfold thickness) and all-cause mortality.
  • To determine the shape and significance of this association across different demographic groups and follow-up durations.

Summary:

  • Univariate analysis revealed an inverted J-shaped relationship between BMI and mortality, with minimal risk at BMI values of 27-29.
  • This pattern was less consistent in women and older men.

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  • Multivariate analysis confirmed the parabolic BMI-mortality association, with the higher-risk left branch potentially influenced by factors like smoking and pre-existing conditions.

    • Impact:

    • Provides crucial insights into the complex association between body weight and mortality risk.
    • Highlights the importance of considering demographic factors and confounding variables in obesity research.
    • Informs public health strategies and clinical guidelines regarding weight management and mortality prediction.