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[Three infants with constipation and muscular weakness: infantile botulism]
Y Thomasse1, J P Arends, P A van der Heide
1Universitair Medisch Centrum Groningen, 9700 RB Groningen.
Nederlands Tijdschrift Voor Geneeskunde
|April 27, 2005
Summary
Infantile botulism, caused by Clostridium botulinum toxin, can present with apathy and weakness in infants. Honey consumption is a risk factor, and infants under 12 months should avoid it.
Area of Science:
- Pediatrics
- Infectious Diseases
- Toxicology
Background:
- Infantile botulism is a rare but serious condition.
- Early diagnosis and intervention are crucial for infant outcomes.
Observation:
- Three previously healthy infants presented with apathy, muscle weakness, and constipation.
- One infant developed respiratory insufficiency, requiring hospitalization.
Findings:
- Clostridium botulinum toxin was detected in the serum of all three infants.
- Type-B toxin was identified in two infants who recovered; Type-A toxin was found in the infant who died.
- Honey consumption was noted in two of the affected infants.
Implications:
- Infantile botulism should be suspected in infants with hypotonia and constipation.
- Electromyography with repetitive stimulation can aid rapid diagnosis.
- Honey is a known source of Clostridium botulinum spores and should be avoided in infants under 12 months.