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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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[Carbohydrate metabolism in children with chronic hepatitis C]

Małgorzata Wiśniewska-Ligier1, Teresa Woźniakowska-Geicka, Joanna Kupś

  • 1III Klinika Pediatrii Instytutu "Centrum Zdrowia Matki Polki" w Lodzi.

Przeglad Lekarski
|April 27, 2005
PubMed

Insights

Carbohydrate metabolism plays a role in chronic hepatitis C. In children with HCV, glucose levels correlated with fibrosis and staging, indicating early risks for hepatic fibrosis.

Area of Science:

  • Hepatology
  • Endocrinology
  • Pediatrics

Context:

  • Chronic hepatitis C (HCV) is increasingly linked to metabolic dysfunction.
  • Understanding carbohydrate metabolism in pediatric HCV is crucial for early intervention.

Purpose:

  • To evaluate carbohydrate metabolism in children with chronic hepatitis C.
  • To investigate potential links between metabolic markers and disease progression in pediatric HCV.

Summary:

  • This study assessed 16 children with chronic hepatitis C and 16 healthy controls, measuring anthropometric data, glucose, insulin, and HOMA IR.
  • No significant differences in BMI, glucose, insulin, or HOMA IR were observed between groups.
  • A significant correlation was found between serum glucose levels and fibrosis (r=0.64, p<0.01) or staging (r=0.7, p<0.004) in children with HCV.

Impact:

  • Findings suggest carbohydrate metabolism is involved in HCV pathogenesis in children.
  • Early detection of metabolic alterations may help predict hepatic fibrosis risk in young patients.
  • Highlights the need for monitoring metabolic health in pediatric HCV cases to prevent long-term complications.
Abstract

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