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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
[Parkinson's disease and depression: commorbidity, signs, etiology, clinical implications]
Hubert Wichowicz1, Jarosław Sławek, Mirosława Derejko
1Klinika Chorób Psychicznych i Zaburzeń Nerwicowych Katedry Chorób Psychicznych Akademii Medycznej w Gdańsku.
Abstract:
Depressive symptoms often occur in Parkinson' disease. They have negative influence for patients' quality of life. However, they are not sufficiently diagnosed nor correctly treated. Difficulties with the diagnosis could be a result of: partial confusion of symptoms of Parkinson's disease and depression and/or different clinical depressive symptoms, compared to "primary" affective disorder. Correlation between cognitive functions, Parkinson' disease and depression remains pretty unclear. Depression occurring during Parkinson's disease must be treated. Theoretically all kinds of treatment for depression can be applied. Nowadays, among antidepressive agents, SSRI's are preferred, mainly because of its good tolerance.
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