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Updated: Aug 18, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
[Current knowledge on diastolic heart failure]
Marcin Misztal1, Andrzej Gackowski, Wiesława Piwowarska
1Klinika Choroby Wieńcowej, Instytutu Kardiologii Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie. mamis@interia.pl
Insights
Diastolic heart failure (DHF) affects many patients with heart failure symptoms but normal systolic function. This review covers DHF definition, causes, symptoms, and current therapeutic guidelines.
Area of Science:
- Cardiology
- Internal Medicine
Context:
- Heart failure (HF) is a leading cause of hospitalization.
- 40-50% of HF patients exhibit normal systolic function, indicating diastolic dysfunction.
- Diastolic heart failure (DHF) is increasingly recognized.
Purpose:
- To define diastolic heart failure (DHF).
- To explore the epidemiology and pathophysiology of DHF.
- To outline diagnostic criteria and therapeutic guidelines for DHF.
Summary:
- DHF involves impaired left ventricular diastolic function, affecting relaxation and filling.
- Pathophysiological mechanisms include myocardial and non-myocardial factors.
- Common contributing conditions include hypertension, coronary artery disease, and diabetes.
Impact:
- Highlights the importance of recognizing DHF distinct from systolic heart failure (SHF).
- Provides a comprehensive overview for clinicians managing HF patients.
- Informs therapeutic strategies based on recent guidelines for DHF management.
Abstract:
Heart failure (HF) is still one of the most common causes of hospitalisation. Originally it was understood as systolic function impairment, but it is prooved that 40 to 50 percent of patients with clinical symptoms of HF have normal systolic function. These data lead to diagnosis of diastolic heart failure (DHF). The diastoly of the left ventricle consists of four stages: isovolumetric relaxation, early mitral inflow, slow mitral inflow and left atrium contraction. Authors have presented definition, epidemiology and basic pathophysiology of DHF. The categories of myocardial and non-myocardial pathogenic mechanisms have also been described. The clinical symptoms that allow to distinguish diastolic from systolic heart failure (SHF) have been pointed. The most common disorders that affect diastolic function like hypertension, coronary artery disease and diabetes have been described. Recent guidelines on therapy in diastolic heart failure have been also presented.
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Pathophysiology of Heart Failure
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