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Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
Kazuya Oshima1, Akihide Nampei, Morihiro Matsuda
1Department of Medicine and Pathophysiology, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Biochemical and Biophysical Research Communications
|April 27, 2005
Summary
Adiponectin hormone boosts bone mass by reducing bone breakdown and enhancing bone formation. This suggests adiponectin could be a therapeutic target for bone loss conditions like osteopenia.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolic Research
Background:
- Adiponectin is an adipose-derived hormone with known roles in insulin sensitivity, hypertension, atherosclerosis, liver fibrosis, and tumor suppression.
- The specific role of adiponectin in regulating bone metabolism has not been fully elucidated.
Purpose of the Study:
- To investigate the effects of adiponectin on bone metabolism, including bone mass, osteoclastogenesis, and osteoblastogenesis.
Main Methods:
- C57BL/6J mice were treated with adenovirus expressing lacZ or adiponectin.
- Bone analysis was performed using three-dimensional microcomputed tomography.
- In vitro studies assessed adiponectin's effects on osteoclast differentiation and activity, and osteoblast function.
Main Results:
- Adiponectin treatment increased trabecular bone mass in mice.
- Osteoclast number and plasma NTx (a bone resorption marker) were decreased following adiponectin treatment.
- Adiponectin inhibited osteoclast differentiation and suppressed osteoclast bone-resorption activity in vitro.
- Adiponectin enhanced osteoblast alkaline phosphatase expression and mineralization activity.
Conclusions:
- Adiponectin increases bone mass by suppressing osteoclastogenesis and activating osteoblastogenesis.
- Adiponectin manipulation may offer therapeutic benefits for conditions characterized by bone loss, such as osteopenia.