Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic-pituitary-adrenocortical axis regulation.

Lauren Jacobson1

  • 1Center for Neuropharmacology and Neuroscience, Albany Medical College, MC-136, Albany, NY 12208, USA. jacobsl@mail.amc.edu

Endocrinology and Metabolism Clinics of North America
|April 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Super-Turbocharged End-to-Side Abductor Digiti Minimi and Anterior Interosseous Double Nerve Transfer Is Associated With Improved Ulnar Intrinsic Function.

Hand (New York, N.Y.)·2024
Same author

Following a Surgical Paradigm Shift Through the Adoption of Nerve Transfers Among Board-Eligible and Practicing Plastic Surgeons.

Hand (New York, N.Y.)·2023
Same author

Abductor Digiti Minimi and Anterior Interosseous to Ulnar Motor Nerve Transfer: The Super Turbocharge End-to-Side Transfer.

Plastic and reconstructive surgery·2023
Same author

Pedicled Groin Flap for Reconstruction of Combined First Webspace and Dorsal Hand Contracture.

Eplasty·2022
Same author

Intramuscular Microvascular Flow Sensing for Flap Monitoring in a Porcine Model of Arterial and Venous Occlusion.

Journal of reconstructive microsurgery·2022
Same author

Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts.

Nature communications·2022

The hypothalamic-pituitary-adrenocortical (HPA) axis demonstrates intricate regulation for survival, adapting to stimuli and stress. Its precise control, including circadian rhythms, balances glucocorticoid effects, with dysregulation linked to disease.

Area of Science:

  • Neuroendocrinology
  • Physiology

Background:

  • The hypothalamic-pituitary-adrenocortical (HPA) axis is crucial for survival, involving complex neuroendocrine regulation.
  • HPA axis control is characterized by both tight regulation and adaptability to various stimuli and stress levels.

Purpose of the Study:

  • To explore the intricate mechanisms governing HPA axis regulation.
  • To understand how HPA axis activity is modulated by stimulus intensity, chronic stress, and circadian rhythms.
  • To investigate the role of glucocorticoids and their receptors in maintaining HPA axis balance and responsiveness.

Main Methods:

  • Analysis of stimulus-specific afferent pathways coding for hypothalamic corticotropin (ACTH) secretagogues.
  • Investigation of combinatorial effects of secretagogues on ACTH secretion.

Related Experiment Videos

  • Examination of alterations in ACTH secretagogue expression and hypothalamic afferent activity under chronic stress.
  • Assessment of circadian HPA activity control and glucocorticoid secretion patterns.

    • Main Results:

    • Specific afferents and secretagogues combine to tailor glucocorticoid responses to stimulus intensity.
    • Chronic stress modifies HPA activity to preserve adrenocortical responsiveness.
    • Circadian control minimizes nadir glucocorticoid secretion, balancing beneficial and adverse effects.
    • Immune and metabolic factors, regulated by glucocorticoids, also influence HPA activity.

    Conclusions:

    • The HPA axis exhibits sophisticated control and plasticity essential for adapting to physiological demands.
    • Dysregulation in HPA axis control mechanisms, influenced by stress, circadian rhythms, and other factors, may underlie various diseases.