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Testing various herbs for antithrombotic effect.
Junichiro Yamamoto1, Kaori Yamada, Aki Naemura
1Laboratory of Physiology, Faculty of Nutrition and High Technology Research Center, Kobe Gakuin University, Kobe, Japan. yamamoto@nutr.kobegakuin.ac.jp
Nutrition (Burbank, Los Angeles County, Calif.)
|April 27, 2005
Summary
Common thyme and rosemary demonstrate significant antithrombotic effects in experimental models. These herbs may prevent arterial thrombotic diseases by directly inhibiting platelet activity.
Area of Science:
- Pharmacology
- Cardiovascular Research
- Herbal Medicine
Background:
- Arterial thrombotic diseases are a major health concern in developed nations.
- Diet plays a crucial role in the risk of thrombotic events.
- Antithrombotic diets offer a potential preventive strategy.
Purpose of the Study:
- To identify herbs with antithrombotic properties.
- To evaluate the potential of herbs in preventing arterial thrombotic diseases.
Main Methods:
- Herbal extracts were prepared and filtered.
- In vitro platelet function was assessed using hemostatometry.
- In vivo antithrombotic activity was evaluated in mice using laser-induced thrombosis.
- Flow-mediated vasodilation was measured after oral administration.
Main Results:
- Common thyme and rosemary exhibited significant antithrombotic activity in both in vitro and in vivo tests.
- Neither herb impacted flow-mediated vasodilation.
- The antithrombotic effects were observed without altering vasodilation.
Conclusions:
- Certain herbs possess demonstrable antithrombotic effects.
- Common thyme and rosemary show promise for preventing thrombosis.
- The mechanism may involve direct inhibition of platelet function.