Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paradoxical undersensing due to quiet timer blanking.

Amy L Beeman1, Gregg Deutsch, Robert F Rea

  • 1Mayo Clinic, Rochester, Minnesota, USA.

Heart Rhythm
|April 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study.

PLoS medicine·2021
Same author

Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors.

Nature communications·2021
Same author

Program and patient characteristics for the United States Expanded Access Program to COVID-19 convalescent plasma.

medRxiv : the preprint server for health sciences·2021
Same author

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19.

The New England journal of medicine·2021
Same author

Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients.

Mayo Clinic proceedings·2020
Same author

Effect of Convalescent Plasma on Mortality among Hospitalized Patients with COVID-19: Initial Three-Month Experience.

medRxiv : the preprint server for health sciences·2020
Same journal

Circumstances and triggering factors for major arrhythmic events in Brugada Syndrome patients without spontaneous type 1 ST elevation.

Heart rhythm·2026
Same journal

Life expectancy, loss-of-life expectancy, medical expenditures, and trends for atrial fibrillation: A population cohort over 20 years.

Heart rhythm·2026
Same journal

Radiofrequency ablation produces stiffer atrial lesions than pulsed-field ablation: in vivo and ex vivo MR elastography in pigs.

Heart rhythm·2026
Same journal

Bidirectional Conduction Within a False Tendon as a Shared Isthmus for Two Distinct Fascicular Ventricular Tachycardias.

Heart rhythm·2026
Same journal

Causal mitochondrial signatures in atrial fibrillation: Insights from integrated multi-omics and multi-faceted approaches.

Heart rhythm·2026
Same journal

Revisiting the Link Between Substrate and Ventricular Tachycardia Rate: The Critical Role of Conduction Isthmus Structure and Function.

Heart rhythm·2026
See all related articles

Pacemakers can misinterpret signals, leading to undersensing of atrial activity. Adjusting sensitivity settings paradoxically resolved this issue, contrary to initial expectations.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Dual chamber pacemakers are crucial for managing bradyarrhythmias.
  • Pacemaker sensing relies on detecting intrinsic cardiac electrical activity.
  • Undersensing, particularly of atrial activity, can compromise device efficacy.

Observation:

  • A specific case demonstrated undersensing of atrial signals by a dual chamber pacemaker.
  • Initial attempts to resolve undersensing involved increasing sensitivity.
  • Increasing pacemaker sensitivity unexpectedly worsened the undersensing problem.

Findings:

  • Reducing the sensitivity voltage threshold successfully eliminated atrial undersensing.
  • This suggests a paradoxical mechanism where excessive sensitivity can lead to signal misinterpretation.

Related Experiment Videos

  • The study reviews the function of pacemaker sense amplifiers in this context.

    • Implications:

    • Clinical implications for pacemaker programming and troubleshooting.
    • Highlights the importance of understanding sense amplifier function.
    • May inform future pacemaker design and algorithm development for improved sensing accuracy.