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Related Experiment Videos

[Optic neuritis associated with infliximab].

T H C Tran1, D Milea, N Cassoux

  • 1Service d'Ophtalmologie, 75013 Paris, France.

Journal Francais D'Ophtalmologie
|April 27, 2005
PubMed
Summary
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Infliximab, a TNFalpha inhibitor, can cause optic neuritis. This case study shows prompt steroid treatment led to a favorable outcome for this rare side effect.

Area of Science:

  • Immunology
  • Ophthalmology
  • Rheumatology

Background:

  • Infliximab is a monoclonal antibody targeting tumor necrosis factor alpha (TNFalpha).
  • It is used for various autoimmune and inflammatory conditions like Crohn disease and rheumatoid arthritis.
  • Adverse effects include infections, antibody development, lymphomas, and demyelinating diseases.

Observation:

  • A patient developed optic neuritis during infliximab treatment.
  • Optic neuritis is inflammation of the optic nerve, potentially causing vision loss.

Findings:

  • This case highlights a rare adverse event of infliximab therapy: optic neuritis.
  • The patient experienced a positive response to systemic steroid administration.

Implications:

Related Experiment Videos

  • Early recognition and intervention with steroids may be crucial for managing infliximab-associated optic neuritis.
  • Further research is needed to understand the mechanisms and incidence of this adverse effect.