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Erythromycin therapy for gastroparesis
1School of Pharmacy, University of Kansas Medical Center, Kansas City 66103.
Southern Medical Journal
|May 1, 1992
Summary
Erythromycin effectively treated idiopathic gastroparesis in two patients when standard prokinetic agents failed. This offers a new therapeutic option for refractory gastroparesis cases.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastroparesis, a condition impairing gastric emptying, is often treated with prokinetic agents.
- Standard treatments include metoclopramide and domperidone, but efficacy is variable.
Observation:
- Two patients with idiopathic gastroparesis had failed to respond to metoclopramide and/or domperidone.
- Erythromycin was administered as a prokinetic agent in these refractory cases.
Findings:
- Successful treatment of idiopathic gastroparesis was achieved using erythromycin in both reported cases.
- Erythromycin demonstrated prokinetic effects, improving gastric motility.
Implications:
- Erythromycin represents a viable alternative prokinetic therapy for gastroparesis when conventional agents are ineffective.
- Further investigation into erythromycin's role in managing gastroparesis is warranted.