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Updated: Aug 18, 2026
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
[Use of optical coherence tomography to study variations of normal parameters with age]
I M Baquero Aranda1, M J Morillo Sánchez, J M García Campos
1Hospital Universitario Virgen de la Victoria de Málaga, Facultad de Medicina, Cátedra de Oftalmología, Málaga.
Purpose:
To determine by Optical Coherence Tomography (OCT) the variation of a variety of measurable parameters (macular thickness, retinal parapapillary fiber layer thickness and optic disc morphology) with age.
Method:
We carried out OCT in 40 normal subjects (80 eyes) aged between 20 and 60 years, divided into 4 groups according to the age decades.
Results:
Statistically significant differences were found in the macular thickness in the comparative study groups but the differences varied according to the sector assessed; the superior outer sector (p=0.00), temporal outer sector (p=0.01), temporal inner sector (p=0.04), nasal inner sector (p=0.03) and inferior inner sector (p=0.00). In the study of retinal parapapillary fiber layer thickness, statistically significant differences were found between groups in the inferior sector only (p=0.04). No statistically significant differences were found between groups in the study of optic disc morphology.
Conclusions:
Both the macular thickness and the nerve fiber layer in the inferior sector decrease with age. These differences in thickness are statistically significant between the extremes of age decades.
