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[Rabbit syndrome due to olanzapine]
Michael Sabolek1, Maria Bayerle
1Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Abteilung Psychiatrie II der Universität Ulm, Bezirkskrankenhaus Günzburg. michael.sabolek@medizin.uni-ulm.de
Psychiatrische Praxis
|April 27, 2005
Summary
Rabbit syndrome, a rare antipsychotic side effect, involves involuntary lip movements. This case report details the first instance of rabbit syndrome occurring in a patient treated with olanzapine.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Rabbit syndrome (RS) is an uncommon extrapyramidal side effect associated with antipsychotic medications.
- It manifests as involuntary, rhythmic lip and mouth dyskinesias, typically excluding the tongue.
- While frequently linked to typical neuroleptics, RS has also been documented with atypical antipsychotics like risperidone and aripiprazole.
Observation:
- A 74-year-old patient diagnosed with bipolar affective disorder was administered 20 mg/d of olanzapine.
- The patient subsequently developed symptoms consistent with rabbit syndrome.
Findings:
- This case represents the first documented instance of rabbit syndrome induced by olanzapine.
- The findings highlight olanzapine as a potential trigger for this specific antipsychotic side effect.
Implications:
- Clinicians should be aware of olanzapine's potential to cause rabbit syndrome.
- This report expands the understanding of atypical antipsychotic-induced movement disorders.
- Further research may be warranted to explore the incidence and mechanisms of RS with olanzapine.