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Lithium-induced nephrogenic diabetes insipidus
Syed Khalid Imam1, Asim Hasan, Syed Khurram Shahid
1Department of Internal Medicine/Endocrinology, Liaquat National Hospital, Karachi.
JPMA. the Journal of the Pakistan Medical Association
|April 28, 2005
Summary
A 43-year-old woman developed lithium-induced nephrogenic diabetes insipidus after 16 years of treatment for bipolar disorder. This case highlights a rare but serious side effect of long-term lithium use.
Area of Science:
- Nephrology
- Psychiatry
- Clinical Pharmacology
Background:
- Lithium carbonate is a common mood stabilizer for bipolar disorder.
- Long-term lithium therapy can lead to various adverse effects.
- Nephrogenic diabetes insipidus is a condition characterized by the kidneys' inability to respond to antidiuretic hormone.
Observation:
- A 43-year-old female patient with a 16-year history of bipolar disorder presented with symptoms of nephrogenic diabetes insipidus.
- The patient was on long-term lithium carbonate treatment.
Findings:
- Diagnostic workup confirmed nephrogenic diabetes insipidus.
- The condition was determined to be secondary to lithium toxicity.
Implications:
- This case underscores the importance of monitoring renal function in patients on long-term lithium therapy.
- Early recognition and management of lithium-induced nephrogenic diabetes insipidus are crucial.
- Understanding this adverse effect profile is vital for clinicians managing bipolar disorder.