Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Novel immunotherapeutic approach].

Tetsuro Kikuchi1

  • 1Dept of Oncology, Institute of DNA Medicine, The Jikei University School of Medicine, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine.

Pharmacology research & perspectives·2026
Same author

Effects of adjunctive brexpiprazole with selective serotonin reuptake inhibitor treatment on anxiety and sleep architecture in mice.

The international journal of neuropsychopharmacology·2026
Same author

Addiction-related problems in Japan: A regional perspective.

Addiction (Abingdon, England)·2025
Same author

Assessing spatiotemporal variability in the concentration and composition of dissolved organic matter and its impact on iron solubility in tropical freshwater systems through a machine learning approach.

The Science of the total environment·2023
Same author

Neuropsychopharmacology renaissance in Japan: A new era after the crisis.

Psychiatry and clinical neurosciences·2023
Same author

Synergistic anti-depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice.

Neuropsychopharmacology reports·2023

Immunotherapy offers a novel approach for malignant gliomas, targeting specific antigens like EGFR and IL-13 R alpha 2. Dendritic cell immunotherapy shows promise in inducing immune responses and antitumor effects in patients.

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Research

Background:

  • Malignant astrocytoma is a common adult primary brain tumor with poor prognosis.
  • Current treatments (surgery, radiotherapy, chemotherapy) offer limited survival benefits.
  • Novel therapeutic strategies, including immunotherapy, are crucial for improving outcomes.

Purpose of the Study:

  • To review immunotherapeutic approaches for malignant gliomas.
  • To assess the relevance of recent clinical trials and their outcomes.
  • To identify potential immunotherapeutic targets and strategies.

Main Methods:

  • Review of existing literature on immunotherapy for malignant gliomas.
  • Identification and analysis of targetable antigens (tenascin, EGFR, IL-13 R alpha 2).

Related Experiment Videos

  • Evaluation of dendritic cell (DC)-based immunotherapy clinical trials.

    • Main Results:

    • Several targetable antigens have been identified in gliomas.
    • Tenascin, EGFR, and IL-13 R alpha 2 are promising targets for immune attack.
    • DC immunotherapy has demonstrated immune responses and clinical antitumor effects in some patients without autoimmune neurotoxicity.

    Conclusions:

    • Immunotherapy, particularly with dendritic cells, represents a promising novel approach for malignant gliomas.
    • Targeting specific antigens like IL-13 R alpha 2 offers new avenues for treatment.
    • Further research and clinical trials are warranted to optimize immunotherapeutic strategies.