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Adderall XR: long acting stimulant for single daily dosing
Floyd R Sallee1, Alexander V Smirnoff
1Department of Psychiatry, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA. floyd.sallee@uc.edu
Expert Review of Neurotherapeutics
|April 28, 2005
Summary
Adderall XR offers a 12-hour duration for treating attention deficit hyperactivity disorder (ADHD) in children and adults. This extended-release formulation demonstrates superior efficacy and improves quality of life, with proven safety and effectiveness.
Area of Science:
- Pharmacology
- Psychiatry
- Pediatrics
Background:
- Adderall XR (SLI381) is a novel psychostimulant formulation providing mixed amphetamine salts in a single daily dose.
- It is indicated for attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.
Purpose of the Study:
- To review the properties, clinical trials, and data for Adderall XR.
- To highlight its distinct two-stage delivery system and combination of active ingredients.
Main Methods:
- Review of clinical trials and meeting reports.
- Analysis of Adderall XR's efficacy, safety, and quality of life impact.
Main Results:
- Adderall XR demonstrates a 12-hour duration of action.
- It shows superior efficacy compared to atomoxetine and significant quality of life improvements in children.
- Proven safety and efficacy in adults with ADHD, with positive findings in oppositional defiant disorder.
Conclusions:
- Adderall XR offers unique advantages due to its delivery system and active ingredients.
- It represents a significant advancement in ADHD therapy for various age groups.